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Furthermore, circulating IGF-1 has been shown to be a critical vasoprotective factor that declines with age, and its deficiency can accelerate vascular aging [165]

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Similarly, the combination of siRNA (JNJ-3989), capsid assembly modulators, and nucleoside analogs achieved significant reductions in HBsAg and viral RNA in chronic hepatitis B patients, while base editing approaches alone have shown promise in targeting cccDNA in primary hepatocyte models [345]